研究業績

論文

  1. Funakoshi K, Koike T, Ise W, Tai Y, Narazaki M, Kumanogoh A, Inoue T, Kurosaki T. TACI is required for the survival of short- and long-lived plasma cells. Int Immunol. Nov 11:dxaf067. (in press) https://doi.org/10.1093/intimm/dxaf067
  2. Fujitani M, Lu X, Shinnakasu R, Inoue T, Kidani Y, Seki NM, Ishida S, Mitsuki S, Ishihara T, Aoki M, Suzuki A, Takahashi K, Takayama M, Ota T, Iwata S, Shibata RY, Sonoyama T, Ariyasu M, Kitano A, Terooatea T, Kelly Villa J, Yamashita K, Yamasaki S, Kurosaki T, Omoto S. Longitudinal analysis of immune responses to SARS-CoV-2 recombinant vaccine S-268019-b in phase 1/2 prime-boost study. Front Immunol. 16:1550279. (2025) https://doi.org/10.3389/fimmu.2025.1550279
  3. Ise W*, Koike T*, Shimada N, Yamamoto H, Tai Y, Shirai T, Kawakami R, Kuwabara M, Kawai C, Shida K, Inoue T, Hojo N, Ichiyama K, Sakaguchi S, Shiroguchi K, Suzuki K, Kurosaki T. KLF2 expression in IgG plasma cells at their induction site regulates the migration program. J Exp Med. 222(5):e20241019. (2025) https://doi.org/10.1084/jem.20241019 *co-first
  4. Inoue T, Baba Y, Kurosaki T. BCR signaling in germinal center B cell selection. Trends Immunol. 45(9):693-704. (2024) https://doi.org/10.1016/j.it.2024.07.005
  5. Inoue T*, Matsumoto Y, Kawai C, Ito M, Nada S, Okada M, Kurosaki T*. Csk restrains BCR-mediated ROS production and contributes to germinal center selection and affinity maturation. J Exp Med. 221(7):e20231996. (2024) https://doi.org/10.1084/jem.20231996.3 *corresponding
  6. Yada Y, Matsumoto M, Inoue T, Baba A, Higuchi R, Kawai C, Yanagisawa M, Kitamura D, Ohga S, Kurosaki T, Baba Y. STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells. J Exp Med. 221(1):e20222178. (2024) https://doi.org/10.1084/jem.20222178
  7. Inoue T, Kurosaki T. Memory B cells. Nat Rev Immunol. 24(1):5-17. (2024) https://doi.org/10.1038/s41577-023-00897-3
  8. Onodera T, Sax N, Sato T, Adachi Y, Kotaki R, Inoue T, Shinnakasu R, Nakagawa T, Fukushi S, Terooatea T, Yoshikawa M, Tonouchi K, Nagakura T, Moriyama S, Matsumura T, Isogawa M, Terahara K, Takano T, Sun L, Nishiyama A, Omoto S, Shinkai M, Kurosaki T, Yamashita K, Takahashi Y. CD62L expression marks SARS-CoV-2 memory B cell subset with preference for neutralizing epitopes. Sci Adv. 9(24):eadf0661. (2023) https://doi.org/10.1126/sciadv.adf0661
  9. Inoue T*. Memory B cell differentiation from germinal centers. Int Immunol. 35(12):565-570. (2023) https://doi.org/10.1093/intimm/dxad017 *corresponding
  10. Inoue T, Shinnakasu R, Kawai C, Yamamoto H, Sakakibara S, Ono C, Itoh Y, Teshima T, Otsuka S, Terooatea T, Okamoto T, Yamashita K, Hashii N, Ishii-Watabe A, Butler NS, Matsuura Y, Matsumoto H, Hiraoka K, Murakami M and Kurosaki T. Antibody feedback contributes to facilitating the development of Omicron-reactive memory B cells in SARS-CoV-2 mRNA vaccinees. J Exp Med. 220(2):e20221786. (2023) https://doi.org/10.1084/jem.20221786
  11. Li, Bern MD, Miao B, Fan C, Xing X, Inoue T, Piersma SJ, Wang T, Colonna M, Kurosaki T, Yokoyama WM. The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function. eLife. 11:e77294. (2022) https://doi.org/10.7554/eLife.77294
  12. Inoue T*, Shinnakasu R, Kurosaki T*. Generation of High Quality Memory B cells. Front Immunol. 12:825813. (2022) https://doi.org/10.3389/fimmu.2021.825813 *corresponding
  13. Lee MSJ, Inoue T, Ise W, Matsuo-Dapaah J, Wing JB, Temizoz B, Kobiyama K, Hayashi T, Patil A, Sakaguchi S, Simon AK, Bezbradica JS, Nagatoishi S, Tsumoto K, Inoue J, Akira S, Kurosaki T, Ishii KJ, Coban C. B cell intrinsic TBK1 is essential for germinal center formation during infection and vaccination. J Exp Med. 219(2):e20211336. (2022) https://doi.org/10.1084/jem.20211336
  14. Lu X, Hosono Y, Nagae M, Ishizuka S, Ishikawa E, Motooka D, Ozaki Y, Sax N, Maeda Y, Kato Y, Morita T, Shinnakasu R, Inoue T, Onodera T, Matsumura T, Shinkai M, Sato T, Nakamura S, Mori S, Kanda T, Nakayama EE, Shioda T, Kurosaki T, Takeda K, Kumanogoh A, Arase H, Nakagami H, Yamashita K, Takahashi Y, Yamasaki S. Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients. J Exp Med. 218(12):e20211327. (2021) https://doi.org/10.1084/jem.20211327
  15. Shinnakasu R, Sakakibara S, Yamamoto H, Wang PH, Moriyama S, Sax N, Ono C, Yamanaka A, Adachi Y, Onodera T, Sato T, Shinkai M, Suzuki R, Matsuura Y, Hashii N, Takahashi Y, Inoue T, Yamashita K, Kurosaki T. Glycan engineering of the SARS-CoV-2 receptor-binding domain elicits cross-neutralizing antibodies for SARS-related viruses. J Exp Med. 218(12):e20211003. (2021) https://doi.org/10.1084/jem.20211003
  16. Onodera T, Kita S, Adachi Y, Moriyama S, Sato A, Nomura T, Sakakibara S, Inoue T, Tadokoro T, Anraku Y, Yumoto K, Tian C, Fukuhara H, Sasaki M, Orba Y, Shiwa N, Iwata N, Nagata N, Suzuki T, Sasaki J, Sekizuka T, Tonouchi K, Sun L, Fukushi S, Satofuka H, Kazuki Y, Oshimura M, Kurosaki T, Kuroda M, Matsuura Y, Suzuki T, Sawa H, Hashiguchi T, Maenaka K, Takahashi Y. A SARS-CoV-2 antibody broadly neutralizes SARS-related coronaviruses and variants by coordinated recognition of a virus-vulnerable site. Immunity. 54(10):2385-2398.e10. (2021) https://doi.org/10.1016/j.immuni.2021.08.025
  17. Inoue T, Shinnakasu R, Kawai C, Ise W, Kawakami E, Sax N, Oki T, Kitamura T, Yamashita K, Fukuyama H, Kurosaki T. Exit from germinal center to become quiescent memory B cells depends on metabolic reprograming and provision of a survival signal. J Exp Med. 218(1):e20200866. (2021) https://doi.org/10.1084/jem.20200866
  18. Tanaka S, Ise W, Inoue T, Ito A, Ono C, Shima Y, Sakakibara S, Nakayama M, Fujii K, Miura I, Sharif J, Koseki H, Koni P, Raman I, Li Q, Kubo M, Fujiki K, Nakato R, Shirahige K, Araki H, Miura F, Ito T, Kawakami E, Baba Y, Kurosaki T. Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity. Nat Immunol. 21(8):950-961. (2020) https://doi.org/10.1038/s41590-020-0700-y
  19. Xu Z, Li S, Rozewicki J, Yamashita K, Teraguchi S, Inoue T, Shinnakasu R, Leach S, Kurosaki T, Standley DM. Functional clustering of B cell receptors using sequence and structural features. Mol Syst Des Eng. 4:769-778. (2019)
  20. Lee MSJ, Natsume-Kitatani Y, Temizoz B, Fujita Y, Konishi A, Matsuda K, Igari Y, Tsukui T, Kobiyama K, Kuroda E, Onishi M, Marichal T, Ise W, Inoue T, Kurosaki T, Mizuguchi K, Akira S, Ishii KJ, Coban C. B cell-intrinsic MyD88 signaling controls IFN-gamma-mediated early IgG2c class switching in mice in response to a particulate adjuvant. Eur J Immunol. 49(9):1433-1440. (2019) https://doi.org/10.1002/eji.201848084
  21. Inoue T, Moran I, Shinnakasu R, Phan TG, Kurosaki T. Generation of memory B cells and their reactivation. Immunol Rev.283(1):138-149. (2018) https://doi.org/10.1111/imr.12640
  22. Herndler-Brandstetter D, Ishigame H, Shinnakasu R, Plajer V, Stecher C, Zhao J, Lietzenmayer M, Kroehling L, Takumi A, Kometani K, Inoue T, Kluger Y, Kaech SM, Kurosaki T, Okada T, Flavell RA. KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. Immunity 48(4):716-729.e8. (2018) https://doi.org/10.1016/j.immuni.2018.03.015
  23. Inoue T, Shinnakasu R, Ise W, Kawai C, Egawa T, Kurosaki T. The transcription factor Foxo1 controls germinal center B cell proliferation in response to T cell help. J Exp Med. 214(4):1181-1198. (2017) https://doi.org/10.1084/jem.20161263
  24. Ogura M, Inoue T, Yamaki J, Homma MK, Kurosaki T, Homma Y. Mitochondrial reactive oxygen species suppress humoral immune response through reduction of CD19 expression in B cells in mice. Eur J Immunol. 47(2):406-418. (2017) https://doi.org/10.1002/eji.201646342
  25. Wing JB, Kitagawa Y, Locci M, Hume H, Tay C, Morita T, Kidani Y, Matsuda K, Inoue T, Kurosaki T, Crotty S, Coban C, Ohkura N, Sakaguchi S. A distinct subpopulation of CD25- T-follicular regulatory cells localizes in the germinal centers. Proc Natl Acad Sci U S A. 114(31):E6400-E6409. (2017) https://doi.org/10.1073/pnas.1705551114
  26. Shinnakasu R, Inoue T, Kometani K, Moriyama S, Adachi Y, Nakayama M, Takahashi Y, Fukuyama H, Okada T, Kurosaki T. Regulated selection of germinal-center cells into the memory B cell compartment. Nat Immunol. 17(7):861-9. (2016) https://doi.org/10.1038/ni.3460
  27. Nakazawa T, Hashimoto R, Sakoori K, Sugaya Y, Tanimura A, Hashimotodani Y, Ohi K, Yamamori H, Yasuda Y, Umeda-Yano S, Kiyama Y, Konno K, Inoue T, Yokoyama K, Inoue T, Numata S, Ohnuma T, Iwata N, Ozaki N, Hashimoto H, Watanabe M, Manabe T, Yamamoto T, Takeda M, Kano M. Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. Nat Commun. 7:10594. (2016) https://doi.org/10.1038/ncomms11466
  28. Inoue T, Morita M, Hijikata A, Fukuda-Yuzawa Y, Adachi S, Isono K, Ikawa T, Kawamoto H, Koseki H, Natsume T, Fukao T, Ohara O, Yamamoto T, Kurosaki T. CNOT3 contributes to early B cell development by controlling Igh rearrangement and p53 mRNA stability. J Exp Med.212(9):1465-79. (2015) https://doi.org/10.1084/jem.20150384
  29. Adachi Y, Onodera T, Yamada Y, Daio R, Tsuiji M, Inoue T, Kobayashi K, Kurosaki T, Ato M, Takahashi Y. Distinct germinal center selection at local sites shapes memory B cell response to viral escape. J Exp Med. 212(10):1709-23. (2015) https://doi.org/10.1084/jem.20142284
  30. Onishi M, Ozasa K, Kobiyama K, Ohata K, Kitano M, Taniguchi K, Homma T, Kobayashi M, Sato A, Katakai Y, Yasutomi Y, Wijaya E, Igarashi Y, Nakatsu N, Ise W, Inoue T, Yamada H, Vandenbon A, Standley DM, Kurosaki T, Coban C, Aoshi T, Kuroda E, Ishii KJ. Hydroxypropyl-beta-cyclodextrin spikes local inflammation that induces Th2 cell and T follicular helper cell responses to the coadministered antigen. J Immunol. 194:2673-82. (2015) https://doi.org/10.4049/jimmunol.1402027
  31. Ise W, Inoue T, McLachlan JB, Kometani K, Kubo M, Okada T, Kurosaki T. Memory B cells contribute to rapid Bcl6 expression by memory follicular helper T cells. Proc Natl Acad Sci U S A. 111(32):11792-7. (2014) https://doi.org/10.1073/pnas.1404671111
  32. Inoue T, Hoshina N, Nakazawa T, Kiyama Y, Kobayashi S, Abe T, Yamamoto T, Manabe T, Yamamoto T. LMTK3 deficiency causes pronounced locomotor hyperactivity and impairs endocytic trafficking. J Neurosci. 34(17):5927-37. (2014) https://doi.org/10.1523/JNEUROSCI.1621-13.2014
  33. Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayashi K, Watanabe M, Kano M, Nakazawa T, Yamamoto T. Protocadherin 17 regulates presynaptic assembly in topographic corticobasal Ganglia circuits. Neuron. 78(5):839-54. (2013) https://doi.org/10.1016/j.neuron.2013.03.031
  34. Ito K,Inoue T, Yokoyama K, Morita M, Suzuki T, Yamamoto T. CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death. Genes Cells. 16:368-79. (2011) https://doi.org/10.1111/j.1365-2443.2011.01492.x
  35. Delawary M, Tezuka T, Kiyama Y, Yokoyama K, Inoue T, Hattori S, Hashimoto R, Umemori H, Manabe T, Yamamoto T, Nakazawa T. NMDAR2B tyrosine phosphorylation regulates anxiety-like behavior and CRF expression in the amygdala. Mol Brain. 3:37. (2010) https://doi.org/10.1186/1756-6606-3-37
  36. Taniguchi S, Nakazawa T, Tanimura A, Kiyama Y, Tezuka T, Watabe AM, Katayama N, Yokoyama K, Inoue T, Izumi-Nakaseko H, Kakuta S, Sudo K, Iwakura Y, Umemori H, Inoue T, Murphy NP, Hashimoto K, Kano M, Manabe T, Yamamoto T. Involvement of NMDAR2A tyrosine phosphorylation in depression-related behavior. EMBO J. 28:3717-29. (2009) https://doi.org/10.1038/emboj.2009.300
  37. Inoue T, Kon T, Ohkura R, Yamakawa H, Ohara O, Yokota J, Sutoh K. BREK/LMTK2 is a myosin VI-binding protein involved in endosomal membrane trafficking. Genes Cells. 13: 483-95. (2008) https://doi.org/10.1111/j.1365-2443.2008.01184.x
  38. Hiyama S, Inoue T, Shima T, Moritani Y, Suda T, Sutoh K. Autonomous loading, transport, and unloading of specified cargoes by using DNA hybridization and biological motor-based motility. Small. 4:410-5. (2008) https://doi.org/10.1002/smll.200700528
  39. Ajima R, Kajiya K, Inoue T, Tani M, Shiraishi-Yamaguchi Y, Maeda M, Segawa T, Furuichi T, Sutoh K, Yokota J. HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth. Biochem Biophys Res Commun. 356:851-6. (2007) https://doi.org/10.1016/j.bbrc.2007.03.060
  40. Inoue T, Kon T, Ajima R, Ohkura R, Tani M, Yokota J, Sutoh K. MYO18B interacts with the proteasomal sugunit Sug1 and is degraded by the ubiquitin-proteasome pathway. Biochem Biophys Res Commun. 342:829-34. (2006) https://doi.org/10.1016/j.bbrc.2006.02.025
  41. Isogawa Y, Kon T, Inoue T, Ohkura R, Yamakawa H, Ohara O, Sutoh K. The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site. Biochemistry. 44:6190-6. (2005) https://doi.org/10.1021/bi0475931

総説

  1. 上滝 隆太郎、小池拓矢、井上毅　ワクチン開発の基盤としての液性免疫記憶研究　生体の科学 76(5):412-413 (2025)
  2. 小池 拓矢、井上毅　免疫記憶研究からのワクチンデザイン　月刊「細胞」 57(11):740-741 (2025)
  3. 井上 毅　胚中心におけるB細胞のポジティブセレクション　臨床免疫・アレルギー科（科学評論社）82(6):651-656 (2024)
  4. 井上 毅　記憶B細胞の分化機構とその多様性　実験医学 42(12):112-117 (2024)
  5. 井上 毅　抗体フィードバック機構による記憶B細胞産生制御　感染・炎症・免疫 54(2):46-47 (2024)
  6. 井上 毅　ワクチンデザインと液性免疫記憶　BIO Clinica 39(6):469-473 (2024)
  7. 井上 毅　単一B細胞解析によるCOVID-19 ｍRNAワクチン応答メカニズムの解明　月刊「細胞」 55(7):83-87 (2023)
  8. 井上 毅　胚中心におけるB細胞レセプターシグナル　臨床免疫・アレルギー科（科学評論社）73(1):38-42 (2020)
  9. 井上 毅　RNA分解酵素複合体CCR4-NOTによるB細胞分化制御　臨床免疫・アレルギー科（科学評論社）64(6):585-589 (2015)
  10. 井上 毅、須藤和夫　ヒトMYO18Aタンパク質とアクチンフィラメントの結合　生体の科学 58(5):436-437 (2007)

著書

  1. 井上 毅　「エッセンシャル免疫学　第4版」第4章（翻訳）、メディカル・サイエンス・インターナショナル (2023)

その他

東京大学 新世代感染症センター

分子免疫システム分野（井上研究室）

〒108-8639　東京都港区白金台4-6-1
東京大学医科学研究所 アムジェンホール

Department of Molecular Systems Immunology
(INOUE Lab)

The UTOPIA Center, The University of Tokyo

4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639 Japan

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